Originally posted by Stiv
При открытии любого проекта .... всё грузится но не проигрывается, вылетает окошко мол - Unable to open audio playback device. Device may not support the current project's audio format or may be in use.
Мож кто сталкивался.......? 
Из Cakewalk сайта:
"Audio Driver Error: The following driver(s) either do not support the current audio format, or are in use by another application.
Users may get this error message when setting the Driver Bit Depth or Sampling Rate beyond the capabilities of the currently selected sound card.
Go to Options > Audio > General and reduce the Driver Bit Depth to 16 and the Sampling Rate to 44.1. This is CD-quality and is the best option for most users. Please keep in mind that while many consumer cards such as the Creative Labs Audigy advertise 24-bit capabilities, their drivers only support 16-bit recording/playback.
If your soundcard's clock can be controlled via an external connection (ie Word Clock, ADAT, etc) or via a control panel, please make sure that the device's current sampling rate matches the settings in SONAR.
Your card may also be in use by another program on the computer. To eliminate this problem, please close all applications running in the background such as Real Player, Winamp, etc and turn off all Windows Sounds from the Control Panel. You may then need to restart SONAR."
Попробуй, может поможет...
